• Susceptibility to hormone-mediated cancer is reflected by different tick rates of the epithelial and general epigenetic clock 

      Barrett, James E.; Herzog, Chiara; Kim, Yoo-Na; Bartlett, Thomas E.; Jones, Allison; Evans, Iona; Cibula, David; Zikan, Michal; Bjørge, Line; Harbeck, Nadia; Colombo, Nicoletta; Howell, Sacha J.; Rådestad, Angelique Flöter; Gemzell-Danielsson, Kristina; Widschwendter, Martin (Journal article; Peer reviewed, 2022)
      Background A variety of epigenetic clocks utilizing DNA methylation changes have been developed; these clocks are either tissue-independent or designed to predict chronological age based on blood or saliva samples. Whether ...
    • The WID-BC-index identifies women with primary poor prognostic breast cancer based on DNA methylation in cervical samples 

      Barrett, James E.; Herzog, Chiara; Jones, Allison; Leavy, Olivia C.; Evans, Iona; Knapp, Susanne; Reisel, Daniel; Nazarenko, Tatiana; Kim, Yoo-Na; Franchi, Dorella; Ryan, Andy; Franks, Joanna; Bjørge, Line; Zikan, Michal; Cibula, David; Harbeck, Nadia; Colombo, Nicoletta; Dudbridge, Frank; Jones, Louise; Sundström, Karin; Dillner, Joakim; Rådestad, Angelique Flöter; Gemzell-Danielsson, Kristina; Pashayan, Nora; Widschwendter, Martin (Journal article; Peer reviewed, 2022)
      Genetic and non-genetic factors contribute to breast cancer development. An epigenome-based signature capturing these components in easily accessible samples could identify women at risk. Here, we analyse the DNA methylome ...